Your doctor may adjust your dose as needed and tolerated. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. What is sirolimus Rapamune? ufco.info vistaril
Danocrine is indicated for the treatment of endometriosis amenable to hormonal management. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. When the dose of Danocrine is doubled the increase in plasma levels is only about 35% to 40%. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Renal side effects have included the retention of nitrogen, sodium, potassium, chloride, water and phosphorus, and decreased urinary excretion of calcium.
Taking danazol to treat endometriosis may increase your risk of ovarian cancer. Talk with your doctor about your individual risk. What should I discuss with my doctor before taking sirolimus Rapamune? Danazol should not be administered to patients with: 1. Undiagnosed abnormal genital bleeding. 2. Markedly impaired hepatic, renal, or cardiac function. 3. Pregnancy.
Following an initial favorable response amenorrhea develops the dosage should be titrated to the minimum dose that suppresses disease activity. In the treatment of fibrocystic breast disease, Danocrine usually produces partial to complete disappearance of nodularity and complete relief of pain and tenderness. Changes in the menstrual pattern may occur. Does Danocrine oral have side effects? Danocrine is indicated for the prevention of attacks of angioedema of all types cutaneous, abdominal, laryngeal in males and females. Side Effects List Danocrine Capsule side effects by likelihood and severity.
Tell your doctor if you become pregnant during treatment. Use effective birth control while you are using this medication and for at least 12 weeks after your treatment ends. Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danocrine on the pituitary-ovarian axis. In this event, treatment may be reinstated. Keep out of the reach of children. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. Danazol may raise the plasma levels of cyclosporin and tacrolimus, leading to an increase of the renal toxicity of these drugs. Monitoring of systemic concentrations of these drugs and appropriate dose adjustments may be needed when used concomitantly with Danazol. What is the most important information I should know about danazol Danocrine? To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non-hormonal birth control method is recommended. This list is not complete and other drugs may interact with sirolimus. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. It is essential that therapy continue uninterrupted for 3 to 6 months but may be extended to 9 months if necessary. After termination of therapy, if symptoms recur, treatment can be reinstituted. Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danazol on the pituitary-ovarian axis. Danazol Capsules USP for oral administration, contain 50 mg, 100 mg or 200 mg of Danazol, USP. Danazol Capsules USP are indicated for the prevention of attacks of angioedema of all types cutaneous, abdominal, laryngeal in males and females. Laboratory monitoring of the hematologic state should be considered.
Makdisi WJ, Cherian R, Vanveldhuizen PJ, Talley RL, Stark SP, Dixon AY "Fatal peliosis of the liver and spleen in a patient with agnogenic myeloid metaplasia treated with danazol. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. If any of these effects persist or worsen, tell your doctor or promptly. What should I discuss with my healthcare provider before taking Danocrine danazol? Undiagnosed abnormal genital bleeding. Danazol can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using danazol. Danazol can increase the calcemic response to alpha calcidol in primary hypoparathyroidism. The following reactions have been reported, a causal relationship to the administration of Danazol has neither been confirmed nor refuted; allergic: urticaria, pruritus and rarely, nasal congestion; CNS effects: headache, nervousness and emotional lability, dizziness and fainting, depression, fatigue, sleep disorders, tremor, paresthesias, weakness, visual disturbances, and rarely, benign intracranial hypertension, anxiety, changes in appetite, chills, and rarely convulsions, Guillain-Barre syndrome; gastrointestinal: gastroenteritis, nausea, vomiting, constipation, and rarely, pancreatitis and splenic peliosis; musculoskeletal: muscle cramps or spasms, or pains, joint pain, joint lockup, joint swelling, pain in back, neck, or extremities, and rarely, carpal tunnel syndrome which may be secondary to fluid retention; genitourinary: hematuria, prolonged posttherapy amenorrhea; hematologic: an increase in red cell and platelet count. Reversible erythrocytosis, leukocytosis or polycythemia may be provoked. Eosinophilia, leukopenia and thrombocytopenia have also been noted. Skin: rashes maculopapular, vesicular, papular, purpuric, petechial and rarely, sun sensitivity, Stevens-Johnson syndrome and erythema multiforme; other: increased insulin requirements in diabetic patients, change in libido, myocardial infarction, palpitation, tachycardia, elevation in blood pressure, interstitial pneumonitis, and rarely, cataracts, bleeding gums, fever, pelvic pain, nipple discharge. Malignant liver tumors have been reported in rare instances, after long-term use. Sirolimus is used to prevent your body from rejecting a transplanted kidney. Sirolimus is sometimes used in a combination treatment with cyclosporine Neoral, Sandimmune and a steroid medicine such as prednisone. MACE in association with use of testosterone replacement therapy in men. Check with your doctor right away if you are a female and have a larger clitoris sexual organ deepening of your voice, or unusual hair growth after taking danazol. Your doctor may advise you to stop taking the medicine so these side effects do not get worse. In most instances, breast pain and tenderness are significantly relieved by the first month and eliminated in 2 to 3 months. Usually elimination of nodularity requires 4 to 6 months of uninterrupted therapy. Regular menstrual patterns irregular menstrual patterns and amenorrhea each occur in approximately one-third of patients treated with 100 mg of Danocrine. Irregular menstrual patterns and amenorrhea are observed more frequently with higher doses. Clinical studies have demonstrated that 50% of patients may show evidence of recurrence of symptoms within one year. In this event, treatment may be reinstated. skelaxin
Danazol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. Sirolimus is usually taken once a day. If you also take cyclosporine, wait at least 4 hours after your cyclosporine dose before you take sirolimus. Before initiating therapy of fibrocystic breast disease with Danocrine, carcinoma of the breast should be excluded. However, nodularity, pain, tenderness due to fibrocystic breast disease may prevent recognition of underlying carcinoma before treatment is begun. Therefore, if any nodule persists or enlarges during treatment, carcinoma should be considered and ruled out. This may not be a complete list of all interactions that may occur. Ask your health care provider if danazol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Schwartz R "Ambiguous genitalia in a term female infant due to exposure to danazol in utero. The information contained in the Truven Health Micromedex products as delivered by Drugs. What other drugs will affect danazol Danocrine? It should not be given intravenously. Danazol has been assigned to pregnancy category X by the FDA. Animal rat studies using danazol at doses 7 to 15 times that of a corresponding human dosage on days 6 to 15 of gestation failed to reveal evidence of teratogenicity or embryotoxicity. Studies in rabbits during days 6 to 18 of gestation at doses 2 to 4 times that of a corresponding human dosage resulted in inhibition of fetal development. There are no controlled data in human pregnancy. Danazol use is considered contraindicated during pregnancy.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Danazol Capsules USP are indicated for the treatment of endometriosis amenable to hormonal management. It is very important that your doctor check your progress at regular visits to make sure that this medicine does not cause unwanted effects. Blood tests may be needed to check for unwanted effects. Flushing, sweating, vaginal dryness and irritation and reduction in breast size, may reflect lowering of estrogen. Nervousness and emotional lability have been reported. In the male a modest reduction in spermatogenesis may be evident during treatment. Abnormalities in semen volume, viscosity, sperm count, and motility may occur in patients receiving long-term therapy. Some of the side effects that can occur with danazol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Therapy should begin during menstruation. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. In the treatment of hereditary angioedema, Danazol at effective doses prevents attacks of the disease characterized by episodic edema of the abdominal viscera, extremities, face, and airway which may be disabling and, if the airway is involved, fatal. In addition, Danazol corrects partially or completely the primary biochemical abnormality of hereditary angioedema by increasing the levels of the deficient C1 esterase inhibitor C1EI. As a result of this action the serum levels of the C4 component of the complement system are also increased. Do not keep outdated medicine or medicine no longer needed. Pearson K, Zimmerman HJ "Danazol and liver damage. These conditions can be made worse by the fluid retention keeping too much body water that can be caused by this medicine. If this occurs, the drug should be discontinued. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. In the treatment of endometriosis, Danocrine alters the normal and ectopic endometrial tissue so that it becomes inactive and atrophic. Complete resolution of endometrial lesions occurs in the majority of cases. brand cefdinir drug
Thromboembolism, thrombotic and thrombophlebitic events including sagittal sinus thrombosis and life-threatening or fatal strokes have been reported. Danazol can increase the calcemic response to synthetic vitamin D analogs in primary hypoparathyroidism. Wentz AC "Adverse effects of danazol in pregnancy. Xiol X, Martinez-Lacasa J, Pons M, Marti E, Casais L "Jaundice after danazol therapy for endometriosis. In moderate to severe disease, or in patients due to endometriosis, a starting dose of 800 mg Danocrine given in two divided doses is recommended. The total daily dosage of Danocrine for fibrocystic breast disease ranges from 100 mg to 400 mg given in two divided doses depending upon patient response. Peress MR, Kreutner AK, Mathur RS, Williamson HO "Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol. What happens if I overdose Rapamune? What is danazol Danocrine? Markedly impaired hepatic, renal, or cardiac function. In moderate to severe disease, or in patients infertile due to endometriosis, a starting dose of 800 mg given in two divided doses is recommended. Amenorrhea and rapid response to painful symptoms is best achieved at this dosage level. Gradual downward titration to a dose sufficient to maintain amenorrhea may be considered depending upon patient response. For mild cases, an initial daily dose of 200 mg to 400 mg given in two divided doses is recommended and may be adjusted depending on patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danazol capsules see and . It is essential that therapy continue uninterrupted for 3 to 6 months but may be extended to 9 months if necessary. After termination of therapy, if symptoms recur, treatment can be reinstituted. Although appropriate studies on the relationship of age to the effects of danazol have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. Nakajima T, Mizushima N, Matsuda H, Matsumoto M, Tamakoshi K, Ishii H, Morioka S, Ikeda Y, Terao T, Kanai K "Fulminant hepatic failure associated with aplastic anaemia after treatment with danazol. Case report. Danazol is usually given for 6 to 9 months to treat fibrocystic breast disease or endometriosis. To prevent attacks of hereditary angioedema, you may need to use the medication long-term. Follow your doctor's instructions. Women who take danazol to treat endometriosis or fibrocystic breast disease should start the medication during a menstrual period. The risk of myopathy and rhabdomyolysis is increased by concomitant administration of Danazol with statins such as simvastatin, atorvastatin and lovastatin. Caution should be exercised if used concomitantly. Consult the product labeling for statin drugs for specific information on dose restrictions in presence of Danazol.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Hory B, Blanc D, Boillot A, Panouse-Perrin J "Guillain-Barre syndrome following danazol and corticosteroid therapy for hereditary angioedema. Capsules of 200 mg orange bottles of 60 NDC 0024-0305-60. Shaw RW, Farquhar JW "Female pseudohermaphroditism associated with danazol exposure in utero. Case report. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60 to 90 days after discontinuation of therapy with Danazol, persistent amenorrhea has occasionally been reported. Kahn H, Manzarbeitia C, Theise N, et al "Danazol-induced hepatocellular adenomas: A case report and review of the literature. Prolongation of prothrombin time occurs in patients stabilized on warfarin. Therapy with danazol may cause an increase in carbamazepine levels in patients taking both drugs. Danazol can cause insulin resistance when used with antidiabetic drugs. Moderate. These medicines may cause some risk when taken together. Danazol may rarely cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness, or other discoloration of the skin, or a severe sunburn. Check with your doctor if this occurs. This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using danazol. prix du lisinopril
Gray RG "Bilateral carpal tunnel syndrome and arthritis associated with Danazol administration. Danazol can cause insulin resistance. Caution should be exercised when used with antidiabetic drugs. Danocrine in the early 90's to treat endometriosis. I was supposed to take it for about 9 months to "simulate pregnancy" by stopping my menstrual cycle long enough to "heal". I could only do it for 3 months, because the side effects were awful. Store at room temperature away from moisture and heat. Do not share this medication with others. This product's label may have been updated. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Genitourinary side effects have included oligospermia and decreased ejaculatory volume. Elderly male patients may experience prostatic enlargement resulting in urinary obstruction. Priapism and excessive stimulation may develop. Seffart G ed. "Drug Dosage in Renal Insufficiency.
Use a barrier form of birth control such as a condom or diaphragm with spermicide. Hormonal contraception such as birth control pills, injections, implants, skin patches, and vaginal rings may not be effective enough to prevent pregnancy during your treatment with danazol. Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit. To assure a female patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Danazol has been associated with several cases of benign intracranial hypertension also known as pseudotumor cerebri. Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea and vomiting, and visual disturbances. Patients with these symptoms should be screened for papilledema and, if present, the patients should be advised to discontinue danazol immediately and be referred to a neurologist for further diagnosis and care. The presence of other medical problems may affect the use of this medicine. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. These hormones usually make the conditions worse. Danocrine of 400 mg or more. It is recommended that patients receiving Danocrine be monitored for hepatic dysfunction by laboratory tests and clinical observation. Serious hepatic toxicity including cholestatic jaundice, peliosis hepatis, and hepatic adenoma have been reported. emsam
The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Drugs. Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. Resolution of pain and tenderness usually occurs following 1 to 3 months of therapy. Elimination of nodules often requires 4 to 6 months of uninterrupted therapy. Symptoms recur within one year in 50% of patients and therapy may be reinitiated if necessary. To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended. Middleton C, McCaughan GW, Painter DM, Stephen MS, Beale M, Fraser I "Danazol and hepatic neoplasia: a case report. Danazol treatment may interfere with laboratory determinations of testosterone, androstenedione and dehydroepiandrosterone. Other metabolic events include a reduction in thyroid binding globulin and T4 with increased uptake of T3, but without disturbance of thyroid stimulating hormone or of free thyroxin index. DANOCRINE, persistent amenorrhea has occasionally been reported. Benzyl alcohol can cross the placenta. See WARNINGS. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. If you have any questions about danazol, please talk with your doctor, pharmacist, or other health care provider. Where can I get more information? Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Clinical studies of Danazol did not include sufficient numbers of subjects aged 65 and over to determine the safety and effectiveness of Danazol in elderly patients. While using danazol, you may need blood tests at your doctor's office. Visit your doctor regularly. The dosage requirements for continuous treatment of hereditary angioedema with Danazol capsules should be individualized on the basis of the clinical response of the patient. It is recommended that the patient be started on 200 mg, two or three times a day. After a favorable initial response is obtained in terms of prevention of episodes of edematous attacks, the proper continuing dosage should be determined by decreasing the dosage by 50% or less at intervals of one to three months or longer if frequency of attacks prior to treatment dictates. If an attack occurs, the daily dosage may be increased by up to 200 mg. During the dose adjusting phase, close monitoring of the patient's response is indicated, particularly if the patient has a history of airway involvement.
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Shepherd J "Danazol and plasma lipoprotein metabolism. Danazol has rarely caused very serious possibly fatal blood clots such as stroke liver disease, and increased pressure on the brain benign intracranial hypertension. If therapy is not initiated during menstruation, a sensitive pregnancy test that detects early pregnancy should be done to determine that the patient is not pregnant. A non-hormonal contraceptive method should be used during danazol therapy. If pregnancy occurs during therapy, danazol should be discontinued. Patients should be advised of the possible risks to the fetus. Current data are insufficient to assess the carcinogenicity of danazol. Your pharmacist can provide more information about sirolimus. Experience with long-term therapy with Danazol is limited. Peliosis hepatis and benign hepatic adenoma have been observed with long-term use. Peliosis hepatis and hepatic adenoma may be silent until complicated by acute, potentially life-threatening intraabdominal hemorrhage. The physician therefore should be alert to this possibility. Attempts should be made to determine the lowest dose that will provide adequate protection. If the drug was begun at a time of exacerbation of hereditary angioneurotic edema due to trauma, stress or other cause, periodic attempts to decrease or withdraw therapy should be considered. In moderate to severe disease, or in patients infertile due to endometriosis, a starting dose of 800 mg given in two divided doses is recommended. Amenorrhea and rapid response to painful symptoms is best achieved at this dosage level. Gradual downward titration to a dose sufficient to maintain amenorrhea may be considered depending upon patient response. For mild cases, an initial daily dose of 200 mg to 400 mg given in two divided doses is recommended and may be adjusted depending on patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danocrine. Inactive Ingredients: Corn Starch, Lactose, Magnesium Stearate, Talc. cost carafate rezeptfrei
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. What should I avoid while taking sirolimus Rapamune? Therapy should continue uninterrupted for 3 to 6 months. Administration of danazol up to 9 months may be necessary. Should symptoms recur, danazol treatment may be reinitiated. Call your doctor at once if you have a serious side effect such as sudden numbness or weakness, problems with vision or speech, chest pain, sudden cough, or wheezing, swelling, rapid weight gain, feeling short of breath, ringing in your ears, dizziness, nausea, pain behind your eyes, stomach pain and loss of appetite, dark urine, or jaundice yellowing of the skin or eyes.
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Do NOT take more medicine than prescribed unless advised to do so by your doctor. How should I take danazol? Take this medication by mouth, usually twice daily or as directed by your doctor. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. aprovel
What is the most important information I should know about sirolimus Rapamune? Do not start, stop, or change the dosage of any medicine before checking with them first. There are no data on the excretion of danazol into human milk. Breast-feeding is considered to be contraindicated by the manufacturer. Before initiating therapy of fibrocystic breast disease with Danazol, carcinoma of the breast should be excluded. However, nodularity, pain, tenderness due to fibrocystic breast disease may prevent recognition of underlying carcinoma before treatment is begun. Therefore, if any nodule persists or enlarges during treatment, carcinoma should be considered and ruled out.
In infrequent patients, symptoms of pain and tenderness may be severe enough to warrant treatment by suppression of ovarian function. Danazol Capsules USP are usually effective in decreasing nodularity, pain, and tenderness. It should be stressed to the patient that this treatment is not innocuous in that it involves considerable alterations of hormone levels and that recurrence of symptoms is very common after cessation of therapy. Store at room temperature away from moisture and heat. What happens if I miss a dose? In rare cases, danazol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. rx drugs rabeprazole
What should I discuss with my healthcare provider before taking danazol Danocrine? Danazol may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use danazol with caution. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.